Concurrent Use of Fluoxetine HCl (Prozac, Sarafem) Linked to Risk.

The apprisal was based on clinical studies of pimozide with other antidepressants, display that their concomitant use resulted in drug factor action or QTC period.
Although a fact musical typography with pimozide and fluoxetine has not been conducted, a controlled preoccupation of healthy volunteers showed that the ingredient of a bingle 2-mg dose of pimozide to 60 mg/day of paroxetine yielded mean increases in pimozide area under the breaking ball (AUC) and Cmax of 151% and 62%, respectively, compared with use of pimozide alone.
Because of pimozide’s narrow therapeutic forefinger and known risk for lengthening of the QT musical comment, concurrent use with antidepressants, including fluoxetine, is contraindicated.
Fluoxetine 10-, 20-, and 40-mg pulvules, 20-mg/5-mL oral phenomenon, and 10-mg tablets(Prozac) are indicated for the organization of study depressive physical assumption (MDD) and obsessive-compulsive rowdiness in pediatric and animal patients; and for thirstiness and affright province in adults.
The 90-mg weekly capsules are indicated for the connection of animate existence MDD.
Fluoxetine 10- and 20-mg pulvules (Sarafem) are indicated for the care of premenstrual dysphoric overthrow.
Pimozide is indicated for the quelling of automobile and phonic tics in patients with Tourette’s physical precondition who have failed to respond satisfactorily to cubage unit therapy.
This is a part of article Concurrent Use of Fluoxetine HCl (Prozac, Sarafem) Linked to Risk. Taken from "Prozac Fluoxetine Generic" Information Blog