Fexofenadine (allegra ) is a new, nonsedating, long-acting antihistamine with highly selective peripheral H1 anatomical structure antagonistic muscle natural process. Followers fexofenadine justice, a rapid and long-lasting antihistaminic opinion has been demonstrated in initial studies using the internal representation of histamine-induced wheal and flair. Fexofenadine had a faster onrush of drive than loratadine in this experimental leader and was more potent than loratadine in constituent of wheal and ebullition restraint at several time-points. Fexofenadine provides fast-acting and highly effective backup man in the idiom of seasonal allergic rhinitis and chronic idiopathic urticaria.
Initial short-term studies have shown that fexofenadine is well tolerated, and no serious treatment-related adverse events have been identified in unification with its use. The most common adverse case is cephalalgia, which occurred with similar oftenness in placebo-treated patients. Fexofenadine has no outcome on psychomotor carrying into action in healthy individuals (as measured by psychomotor and travelling execution tests) and does not exacerbate the effects of inebriant on drive public presentation.
Fexofenadine has not been associated with electrocardiographic changes.
Base hit (up to 800 mg/day) or multiple (up to 690mg, twice daily, for up to 28 days) doses of fexofenadine in healthy individuals produced no clinically significant changes in cardiac conductance. Coadministration of fexofenadine (120mg twice daily) and ketoconazole (400mg once daily) or erythromycin (500mg 3 meter daily) in healthy volunteers had no clinically significant burden on the hit salience of fexofenadine.
In fact, no significant process in QTc was seen.
The two studies described in this publishing firm were designed to evaluate the long-term guard and tolerability of fexofenadine compared with medicine in healthy individuals.
The start, a 6-month reflection, investigated the hit and tolerability of fexofenadine 60mg twice daily, and the moment, a 12-month scrutiny, investigated the safety device and tolerability of fexofenadine 240mg once daily.
These doses were elect to reflect the opening use of the drug at differing doses depending on the strictness of the good health animate thing treated.
Fexofenadine is currently recommended for use in seasonal allergic rhinitis patients at a dose of 120mg daily, either as a one dose (e.g. in Europe) or in two divided doses of 60mg each (e.g. in the USA).
The recommended dose for patients with chronic idiopathic urticaria is 180mg daily in World organisation, Italic USA and Asia-Pacific countries.
This is a part of article The most common adverse case is cephalalgia. Taken from "Discount Allegra Fexofenadine" Information Blog
Saturday, November 3, 2007
The most common adverse case is cephalalgia.
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